Quantitative trait locus detection using combined linkage/disequilibrium analysis
نویسندگان
چکیده
منابع مشابه
Quantitative trait locus analysis.
Alcoholism is a quantitative disorder that is caused by the combined influences of numerous genes (i.e., quantitative trait loci [QTLs]) and environmental factors. To identify QTLs for alcoholism, researchers compare subject groups (e.g., inbred mouse strains) that differ in both their genetic makeup (i.e., genotype) and alcohol-related trait (e.g., sensitivity to certain alcohol effects). Usin...
متن کاملCombined Expression Trait Correlations and Expression Quantitative Trait Locus Mapping
Coordinated regulation of gene expression levels across a series of experimental conditions provides valuable information about the functions of correlated transcripts. The consideration of gene expression correlation over a time or tissue dimension has proved valuable in predicting gene function. Here, we consider correlations over a genetic dimension. In addition to identifying coregulated ge...
متن کاملQuantitative Trait Locus Analysis, Pathway
Coxsackievirus B3 (CVB3) infection is the most common cause of viral myocarditis. The pathogenesis of viral myocarditis is strongly controlled by host genetic factors. Although certain indispensable components of immunity have been identified, the genes and pathways underlying natural variation between individuals remain unclear. Previously, we isolated the viral myocarditis susceptibility 1 (V...
متن کاملDetection of Quantitative Trait Associated Genes Using Cluster Analysis
Many efforts have been involved in association study of quantitative phenotypes and expressed genes. The key issue is how to efficiently identify phenotype-associated genes using appropriate methods. The limitations for the existing approaches are discussed. We propose a hierarchical mixture model in which the relationship between gene expressions and phenotypic values is described using orthog...
متن کاملQuantitative trait locus analysis of longitudinal quantitative trait data in complex pedigrees.
There is currently considerable interest in genetic analysis of quantitative traits such as blood pressure and body mass index. Despite the fact that these traits change throughout life they are commonly analyzed only at a single time point. The genetic basis of such traits can be better understood by collecting and effectively analyzing longitudinal data. Analyses of these data are complicated...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 1999
ISSN: 0741-0395
DOI: 10.1002/gepi.1370170706